Urolithin B

• Description:

  Urolithin B is one of Ellagitannins' slow microbial products, and has anti-inflammatory and anti-inflammatory effects. Urolithin B suppresses NF-κB activity. Urolithin B suppresses JNK, ERK and Akt's oxidation, and increases AMPK's oxidation. Urolithin B is also a quantitative change factor for bone and skin quality[1][2][3][4].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Akt; AMPK; Endogenous Metabolite; ERK; JNK; NF-κB

• Type:

  Natural Products

• Related Pathways:

  Epigenetics; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR; Stem Cell/Wnt

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/urolithin-b.html

• Concentration:

  10mM

• Purity:

  99.91

• Solubility:

  DMSO : 200 mg/mL (ultrasonic)

• Smiles:

  O=C1C2=CC=CC=C2C3=CC=C(O)C=C3O1

• Molecular Formula:

  C13H8O3

• Molecular Weight:

  212.20

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Lee G, et al. Anti-inflammatory and antioxidant mechanisms of urolithin B in activated microglia. Phytomedicine. 2019 Mar 1;55:50-57.|[2]Rodriguez J, et al. Urolithin B, a newly identified regulator of skeletal muscle mass. J Cachexia Sarcopenia Muscle. 2017 Aug;8 (4) :583-597.|[3]Lv MY, et al. Urolithin B suppresses tumor growth in hepatocellular carcinoma through inducing the inactivation of Wnt/β-catenin signaling. J Cell Biochem. 2019 Oct;120 (10) :17273-17282.|[4]Rodriguez J, et al. Urolithin B, a newly identified regulator of skeletal muscle mass. J Cachexia Sarcopenia Muscle. 2017 Aug;8 (4) :583-597.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  Human Endogenous Metabolite

• CAS Number:

  1139-83-9