Products for Research Use Only
RegisterLogin

Urolithin D

CAT: 0804-HY-133178-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-133178-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Urolithin D (3,4,8,9-Tetrahydroxy urolithin) is a colonic metabolite of Ellagitannins and a competitive, reversible, and selective antagonist of the EphA receptor. Urolithin D inhibits EphA2-ephrin-A1 binding with an IC50 of 0.9 μM. Urolithin D is also a potent antioxidant that scavenges free radicals and repairs oxidized DNA damage. Additionally, Urolithin D suppresses triglyceride accumulation and promotes fatty acid oxidation by activating the AMPK signaling pathway. Urolithin D can be used for research on tumors, metabolic, and inflammatory diseases[1][2][3].
CAS Number
131086-98-1
Product Name Alternative
3,4,8,9-Tetrahydroxy urolithin
UNSPSC
12352005
Hazard Statement
H315, H319
Target
AMPK; Ephrin Receptor; PPAR
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Vitamin D Related/Nuclear Receptor
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/urolithin-d.html
Purity
99.72
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C1C2=CC(O)=C(O)C=C2C3=CC=C(O)C(O)=C3O1
Molecular Formula
C13H8O6
Molecular Weight
260.20
Precautions
H315, H319
References & Citations
[1]Giorgio C, et al. The ellagitannin colonic metabolite urolithin D selectively inhibits EphA2 phosphorylation in prostate cancer cells. Mol Nutr Food Res. 2015 Nov;59 (11) :2155-67. |[2]Kang I, et al. Urolithin A, C, and D, but not iso-urolithin A and urolithin B, attenuate triglyceride accumulation in human cultures of adipocytes and hepatocytes. Mol Nutr Food Res. 2016 May;60 (5) :1129-38.|[3]Milanović Ž. Urolithin D: A promising metabolite of ellagitannin in combatting oxidative stress. Chem Biol Interact. 2025 Apr 25;411:111444.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
EphA; PPARγ

Related Products

CatalogName
HY-100599-01Urolithin A
HY-N7922-01Urolithin M5
HY-100599S2Urolithin A-13C6
HY-100599R-01Urolithin A (Standard)
HY-N8049-01Urolithin M7
HY-135897-01Urolithin C
HY-126307-01Urolithin B
HY-W746164-01Urolithin E
HY-N7921-01Urolithin M6
HY-126307R-01Urolithin B (Standard)

Alternative Products

CatalogName
B7945-25Urolithin A
B1155-5Urolithin A

Popular Products