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Ki16425 (Standard)

CAT: 0804-HY-13285R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13285R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ki16425 (Standard) is the analytical standard of Ki16425. This product is intended for research and analytical applications. Ki16425 (Debio 0719) is a subtype-selective, competitive antagonist of the EDG-family receptors, LPA1 and LPA3 with Kis of 0.34 μM and 0.93 μM, respectively. Ki16425 (Debio 0719) reduces the LPA-induced activation of p42/p44 MAPK[1][2]. Ki16425 can also inhibit LPA-induced dephosphorylation of Yes-associated protein (YAP) /TAZ in HEK293A cells[3].
CAS Number
355025-24-0
UNSPSC
12352100
Target
LPL Receptor; Reference Standards; YAP
Related Pathways
GPCR/G Protein; Others; Stem Cell/Wnt
Field of Research
Neurological Disease; Cancer
Smiles
ClC1=C(C=CC=C1)C(C)OC(NC2=C(ON=C2C)C3=CC=C(C=C3)CSCCC(O)=O)=O
Molecular Formula
C23H23ClN2O5S
Molecular Weight
474.96
References & Citations
[1]Ohta H, et al. Ki16425, a subtype-selective antagonist for EDG-family lysophosphatidic acid receptors.Mol Pharmacol, 2003, 64 (4), 994-1005.|[2]Moughal NA, et al. Protean agonism of the lysophosphatidic acid receptor-1 with Ki16425 reduces nerve growth factor-induced neurite outgrowth in pheochromocytoma 12 cells. J Neurochem, 2006, 98 (6), 1920-1929.|[3]Ma L, et al. Evidence for lysophosphatidic acid 1 receptor signaling in the early phase of neuropathic pain mechanisms in experiments using Ki-16425, a lysophosphatidic acid 1 receptor antagonist. J Neurochem, 2009, 109 (2), 603-610.|[4]Yu FX, et al. Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. Cell. 2012 Aug 17;150 (4) :780-91.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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CatalogName
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