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Ki16425

CAT: 0804-HY-13285-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13285-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ki16425 (Debio 0719) is a subtype-selective, competitive antagonist of the EDG-family receptors, LPA1 and LPA3 with Kis of 0.34 μM and 0.93 μM, respectively. Ki16425 (Debio 0719) reduces the LPA-induced activation of p42/p44 MAPK[1][2]. Ki16425 can also inhibit LPA-induced dephosphorylation of Yes-associated protein (YAP) /TAZ in HEK293A cells[3].
CAS Number
355025-24-0
Product Name Alternative
Debio 0719
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
LPL Receptor; YAP
Type
Reference compound
Related Pathways
GPCR/G Protein; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/ki16425.html
Purity
98.88
Solubility
DMSO : ≥ 100 mg/mL
Smiles
ClC1=C(C=CC=C1)C(C)OC(NC2=C(ON=C2C)C3=CC=C(C=C3)CSCCC(O)=O)=O
Molecular Formula
C23H23ClN2O5S
Molecular Weight
474.96
Precautions
H302, H315, H319, H335
References & Citations
[1]Ohta H, et al. Ki16425, a subtype-selective antagonist for EDG-family lysophosphatidic acid receptors.Mol Pharmacol, 2003, 64 (4), 994-1005.|[2]Moughal NA, et al. Protean agonism of the lysophosphatidic acid receptor-1 with Ki16425 reduces nerve growth factor-induced neurite outgrowth in pheochromocytoma 12 cells. J Neurochem, 2006, 98 (6), 1920-1929.|[3]Ma L, et al. Evidence for lysophosphatidic acid 1 receptor signaling in the early phase of neuropathic pain mechanisms in experiments using Ki-16425, a lysophosphatidic acid 1 receptor antagonist. J Neurochem, 2009, 109 (2), 603-610.|[4]Yu FX, et al. Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. Cell. 2012 Aug 17;150 (4) :780-91.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
YAP/TAZ

Alternative Products

CatalogName
453044-01Ki16425

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