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Flonoltinib (sulfate)

CAT: 0804-HY-130247CSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-130247CSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Flonoltinib maleate is a potent and orally active dual JAK2/FLT3 inhibitor with IC50 values of 0.7 nM, 4 nM, 26 nM and 39 nM for JAK2, FLT3, JAK1 and JAK3, respectively. Flonoltinib maleate has anti-cancer activity[1].
CAS Number
2568842-57-7
Product Name Alternative
JAK2/FLT3-IN-1 (sulfate)
UNSPSC
12352005
Target
Apoptosis; FLT3; JAK
Related Pathways
Apoptosis; Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Cancer
Smiles
O=S(O)(O)=O.FC1=CC(NC2=NC(C3=CN(C(C)C)N=C3)=C(C)C=N2)=CC=C1N4CCC(CC4)N(CCO)C
Molecular Formula
C25H36FN7O5S
Molecular Weight
565.66
References & Citations
[1]Yang T, et al. Discovery of Potent and Orally Effective Dual JAK2/FLT3 Inhibitors for the Treatment of AcuteMyelogenous Leukemia and Myeloproliferative Neoplasms. J Med Chem. 2019 Oct 31.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

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Alternative Products

CatalogName
GTR19250488-01Flonoltinib sulfate
C03307-25mgFlonoltinib
T89283-01Flonoltinib maleate
A24219-50Flonoltinib (JAK2/FLT3-IN-1) 50mg
A24219-100Flonoltinib (JAK2/FLT3-IN-1) 100mg
A24219-10Flonoltinib (JAK2/FLT3-IN-1) 10mg
A24219-5Flonoltinib (JAK2/FLT3-IN-1) 5mg
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