Flonoltinib (TFA)
CAT:
804-HY-130247A-03
Size:
10 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Flonoltinib (TFA)
- Product Name Alternative: JAK2/FLT3-IN-1 (TFA)
- CAS Number: 2928093-29-0
- UNSPSC Description: JAK2/FLT3-IN-1 (TFA) is a potent and orally active dual JAK2/FLT3 inhibitor with IC50 values of 0.7 nM, 4 nM, 26 nM and 39 nM for JAK2, FLT3, JAK1 and JAK3, respectively. JAK2/FLT3-IN-1 (TFA) has anti-cancer activity[1].
- Target Antigen: Apoptosis; FLT3; JAK
- Type: Reference compound
- Related Pathways: Apoptosis;Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/flonoltinib-tfa.html
- Purity: 99.77
- Solubility: H2O : 33.33 mg/mL (ultrasonic)
- Smiles: OCCN(C1CCN(C2=CC=C(NC3=NC=C(C)C(C4=CN(C(C)C)N=C4)=N3)C=C2F)CC1)C.O=C(O)C(F)(F)F
- Molecular Weight: 581.61
- References & Citations: [1]Yang T, et al. Discovery of Potent and Orally Effective Dual JAK2/FLT3 Inhibitors for the Treatment of AcuteMyelogenous Leukemia and Myeloproliferative Neoplasms. J Med Chem. 2019 Oct 31.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
- Clinical Information: Phase 2