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KMUP-1

CAT: 0804-HY-129670Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-129670Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KMUP-1 is a xanthine derivative with vasodilator activity. KMUP-1 is a inhibitor of phosphodiesterase (PDE) and activator of soluble guanylyl cyclase (sGC) . KMUP-1 stimulates NO/sGC/cyclic GMP pathway. KMUP-1 has K+ channels opening activity. KMUP-1 ameliorates ischemia-induced cardiomyocyte apoptosis. KMUP-1 can be used for cardiovascular and anti-inflammatory study[1][2].
CAS Number
81996-46-5
UNSPSC
12352005
Hazard Statement
H301-H315-H319-H335
Target
Apoptosis; Guanylate Cyclase; Phosphodiesterase (PDE) ; Potassium Channel
Related Pathways
Apoptosis; GPCR/G Protein; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Purity
90.000000
Smiles
O=C(N1C)N(C)C2=C(N(CCN3CCN(C4=CC=CC=C4Cl)CC3)C=N2)C1=O
Molecular Formula
C19H23ClN6O2
Molecular Weight
402.88
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Wu BN, et al. A xanthine-based KMUP-1 with cyclic GMP enhancing and K (+) channels opening activities in rat aortic smooth muscle. Br J Pharmacol. 2001 Sep;134 (2) :265-74. |[2]Lee ML, et al. KMUP-1 Ameliorates Ischemia-Induced Cardiomyocyte Apoptosis through the NO⁻cGMP⁻MAPK Signaling Pathways. Molecules. 2019 Apr 8;24 (7) :1376.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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