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KMUP-4

CAT: 0804-HY-129210Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-129210Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KMUP-4, as a xanthine derivative with cGMP-enhancing activity, induces aortic relaxation through endothelium-dependent and independent mechanisms. KMUP-4 increases cytoplasmic cyclic guanosine monophosphate (cGMP) and cyclic adenosine monophosphate (cAMP) levels by inhibiting phosphodiesterases (PDEs) and activating K+ channels. KMUP-4 can be used in the study of cardiovascular diseases[1].
CAS Number
864873-81-4
UNSPSC
12352005
Target
Phosphodiesterase (PDE) ; Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/kmup-4.html
Smiles
O=C1C2=C(N(C(N1C)=O)C)N=CN2CCN3CCN(CC3)C4=C(C=CC=C4)[N+]([O-])=O
Molecular Formula
C19H23N7O4
Molecular Weight
413.43
References & Citations
[1]BN Wu, et al. Aortic Smooth Muscle Relaxants KMUP-3 and KMUP-4, Two Nitrophenylpiperazine Derivatives of Xanthine, Display cGMP-Enhancing Activity: Roles of Endothelium, Phosphodiesterase, and K:+: Channel. Journal of cardiovascular pharmacology 46.5 (2005) : 600-608.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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