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Pulrodemstat (hydrochloride)

CAT: 0804-HY-129388CSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-129388CSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pulrodemstat (CC-90011) hydrochloride is a potent, selective, reversible and orally active inhibitor of lysine specific demethylase-1 (LSD1) with an IC50 value of 0.25 nM. Pulrodemstat hydrochloride is less enzymatic inhibition against LSD2, MOA-A, and MAO-B. Pulrodemstat hydrochloride induces acute myeloid leukemia (AML) and small cell lung cancer (SCLC) cells differentiation and has potent anticancer activity[1].
CAS Number
1821307-11-2
Product Name Alternative
CC-90011 (hydrochloride) ; LSD1-IN-7 (hydrochloride)
UNSPSC
12352005
Target
Histone Demethylase
Related Pathways
Epigenetics
Field of Research
Cancer
Smiles
N#CC1=CC=C(C(N=C(N2CCC(N)CC2)N3C)=C(C4=CC=C(OC)C(F)=C4)C3=O)C=C1F.Cl
Molecular Formula
C24H24ClF2N5O2
Molecular Weight
487.93
References & Citations
[1]Toufike Kanouni, et al. Discovery of CC-90011: A Potent and Selective Reversible Inhibitor of Lysine Specific Demethylase 1 (LSD1) . J Med Chem. 2020 Dec 10;63 (23) :14522-14529.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
KDM1/LSD1

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