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9-cis-Retinal

CAT: 0804-HY-W009310-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W009310-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
9-cis-Retinal is a natural retinoid. Dietary 9-cis-β-carotene generates 9-cis-retinoids via cleavage into 9-cis-retinal. 9-cis Retinal binds to cellular retinol-binding protein-I (CRBP-I) and CRBP-II with Kds of 8 nM and 5 nM, respectively. 9-cis-Retinal expedites differentiation and maturation of rod photoreceptors in retinal organoids[1][2][3].
CAS Number
514-85-2
UNSPSC
12352211
Hazard Statement
H302+H312+H332, H315
Target
Endogenous Metabolite; Organoid
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease; Stem Cell/Wnt
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/9-cis-retinal.html
Purity
99.9
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(/C=C/C=C(\C=C\C1=C(CCCC(C)1C)C)C)=C\C=O
Molecular Formula
C20H28O
Molecular Weight
284.44
Precautions
H302+H312+H332, H315
References & Citations
[1]Kane MA, et al. Binding affinities of CRBPI and CRBPII for 9-cis-retinoids.Biochim Biophys Acta. 2011 May;1810 (5) :514-8.|[2]Mertz JR, et al. Identification and characterization of a stereospecific human enzyme that catalyzes 9-cis-retinol oxidation. A possible role in 9-cis-retinoic acid formation. J Biol Chem. 1997 May 2;272 (18) :11744-9.|[3]Kaya KD, et al. Transcriptome-based molecular staging of human stem cell-derived retinal organoids uncovers accelerated photoreceptor differentiation by 9-cis retinal. Mol Vis. 2019 Nov 11;25:663-678.|[4]Parker RO, et al. Normal cone function requires the interphotoreceptor retinoid binding protein. J Neurosci. 2009 Apr 8;29 (14) :4616-21.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite

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