AM-6761

CAT: 0804-HY-12737Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-12737Size:1 Each
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Description
AM-6761 is a potent MDM2 inhibitor with an IC50 of 0.1 nM.
CAS Number
[1584732-36-4]
UNSPSC
12352005
Target
E1/E2/E3 Enzyme; MDM-2/p53
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Field of Research
Cancer
Solubility
10 mM in DMSO
Smiles
O=C(O)CC1=CN=C(C[C@]2(C)C(N([C@@H](C3CC3)CS(=O)(C(C)(C)C)=O)[C@H](C4=CC=C(Cl)C(F)=C4)[C@@H](C5=CC=CC(Cl)=C5)C2)=O)S1
Molecular Formula
C33H37Cl2FN2O5S2
Molecular Weight
695.69
References & Citations
[1]Gonzalez AZ, et al. Novel inhibitors of the MDM2-p53 interaction featuring hydrogen bond acceptors as carboxylic acid isosteres. J Med Chem. 2014 Apr 10;57 (7) :2963-88.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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