BAY-866

• Description :

  BAY-866, a sulfamide campound, is an allosteric MEK1 inhibitor with an IC50 of 14 nM. BAY-866 inhibits cell growth of A375 (BRAF) and HCT116 (K-Ras) with IC50s of 13 nM and 277 nM, respectively. BAY-866 inhibits tumor growth in K-Ras-mutated A549 xenograft model[1].

• CAS Number :

  [1836185-18-2]

• UNSPSC :

  12352005

• Target :

  MEK

• Related Pathways :

  MAPK/ERK Pathway

• Field of Research :

  Cancer

• Smiles :

  O=C(C1=C(C=C(C(F)=C1NC2=CC=C(C=C2F)I)F)OC3=CC=C(C(NS(=O)(N)=O)=C3)F)N

• Molecular Formula :

  C19H13F4IN4O4S

• Molecular Weight :

  596.29

• References & Citations :

  [1]Hartung IV, et al. Optimization of allosteric MEK inhibitors. Part 2: Taming the sulfamide group balances compound distribution properties. Bioorg Med Chem Lett. 2016 Jan 1;26 (1) :186-93.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported