NWL-117

• Description :

  NWL-117 is a brain-penetrant and highly selective Caspase-6 (Casp6) inhibitor with an IC50 value of 192 nM. NWL-117 is promising for research of neurodegenerative diseases, particularly Alzheimer's disease and Huntington's disease [1].

• UNSPSC :

  12352005

• Target :

  Caspase

• Related Pathways :

  Apoptosis

• Field of Research :

  Neurological Disease

• Smiles :

  O=C(O)[C@@H](/C=C/S(=O)(C)=O)NC([C@H]([C@@H](C)CC)NC([C@H](CCC(O)=O)NC([C@H](C(C)C)NC(OCC1=CC=CC=C1)=O)=O)=O)=O

• Molecular Formula :

  C29H42N4O11S

• Molecular Weight :

  654.73

• References & Citations :

  [1]Pakavathkumar P, et al. Caspase vinyl sulfone small molecule inhibitors prevent axonal degeneration in human neurons and reverse cognitive impairment in Caspase-6-overexpressing mice. Mol Neurodegener. 2017 Feb 28;12 (1) :22.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2267318-43-2]