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EGFR-IN-117

CAT: 0931-T88785-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T88785-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3035639-05-2
Target
EGFR, Apoptosis
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis, JAK/STAT signaling, Apoptosis
Bioactivity
EGFR-IN-117 (Compound 8h) exhibits inhibitory activity against EGFR mutations, specifically targeting the tumor environment and inducing apoptosis in cancer cells. This compound effectively inhibits the proliferation of H1975, PC-9, and mutant EGFR cells including BaF3-EGFRL858R/T790M/C797S and BaF3–C797S/Del19/T790M, with IC50 values of 13 nM, 19 nM, 1.2 nM, and 1.3 nM respectively. Additionally, EGFR-IN-117 demonstrates anti-tumor activity in mouse models.
Smiles
O=S(=O)(NC=1C=CC=CC1NC2=NC(=NC=C2Br)NC3=CC=C(C=C3)N4CCN(C)CCC4)C5CC5
Molecular Formula
C25H30BrN7O2S
Molecular Weight
572.52
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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