X-370

• Description :

  X-370 is a PI3Kδ inhibitor (IC50 = 7 nM) . X-370 inhibits the survival of leukemia cells, inducing G1 arrest and apoptosis. X-370 blocks PDK1 binding and phosphorylation of MEK1/2, eliminating Akt and Erk1/2 signaling. X-370 can be used in research on B-cell acute lymphoblastic leukemia (B-ALL) [1].

• UNSPSC :

  12352005

• Target :

  Akt; Apoptosis; ERK; MEK; PDK-1; PI3K

• Related Pathways :

  Apoptosis; MAPK/ERK Pathway; PI3K/Akt/mTOR; Stem Cell/Wnt

• Field of Research :

  Cancer

• Smiles :

  FC(F)C1=NC2=C(N1C3=NC(N4CCOCC4)=NC5=C3N=CN5C6CCN(C(N7CCCC7)=O)CC6)C=CC=C2

• Molecular Formula :

  C27H31F2N9O2

• Molecular Weight :

  551.59

• References & Citations :

  [1]Wang X, et al. Simultaneous targeting of PI3Kδ and a PI3Kδ-dependent MEK1/2-Erk1/2 pathway for therapy in pediatric B-cell acute lymphoblastic leukemia. Oncotarget. 2014 Nov 15;5 (21) :10732-44.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1280725-80-5]