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A-423579

CAT: 0804-HY-12192Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-12192Size:1 Each
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Description
A-423579 is an orally active non-imidazole histamine H3 receptor antagonist. A-423579 exhibits high affinity and good selectivity for human and rat H3 receptors, and possesses both antagonistic and inverse agonistic activities. A-423579 can effectively reduce body weight in obese rodents, with concomitant decreases in fat content, plasma leptin levels, and triglycerides. A-423579 possesses anti-obesity activity and can be used in the research of obesity and related metabolic disorders[1][2].
CAS Number
461045-17-0
UNSPSC
12352005
Target
Histamine Receptor
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Field of Research
Metabolic Disease
Smiles
CN([C@@H]1CCN(CCCOC2=C(F)C=C(C3=CC=C(C#N)C=C3)C=C2F)C1)C
Molecular Formula
C22H25F2N3O
Molecular Weight
385.45
References & Citations
[1]Hancock AA, et al. Antiobesity evaluation of histamine H3 receptor (H3R) antagonist analogs of A-331440 with improved safety and efficacy. Inflamm Res. 2005 Apr;54 Suppl 1:S27-9.|[2]Masaki T, et al. Therapeutic approach of histamine H3 receptors in obesity. Recent Pat CNS Drug Discov. 2007 Nov;2 (3) :238-40.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
H3 Receptor

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