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Dopal (purity>80%)

CAT: 0804-HY-121252ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-121252ASize:1 Each
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Description
Dopal (purity>80%) is an aldehyde that can be generated in Parkinson's disease by enzymatic degradation of dopamine. Dopal (purity>80%) can generate reactive oxygen species (ROS), and triggers aggregation of α-synuclein. Dopal (purity>80%) elicits α-synuclein accumulation and hampers α-synuclein clearance in primary neurons[1][2].
CAS Number
5707-55-1
UNSPSC
12352005
Target
α-synuclein
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
O=CCC1=CC=C(O)C(O)=C1
Molecular Formula
C8H8O3
Molecular Weight
152.15
References & Citations
[1]Masato A, et al. DOPAL initiates αSynuclein-dependent impaired proteostasis and degeneration of neuronal projections in Parkinson's disease. NPJ Parkinsons Dis. 2023 Mar 25;9 (1) :42. |[2]Bloch DN, et al. Scavenging neurotoxic aldehydes using lysine carbon dots. Nanoscale Adv. 2023 Jan 19;5 (5) :1356-1367.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
α-synuclein Aggregation

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