GUT-70

• Description:

  GUT-70, a tricyclic coumarin, is a Hsp90 inhibitor. GUT-70 activates the caspase 2, 3, 8 and 9, and induces the apoptosis in leukemic cells. GUT-70 inhibits HIV-1 replication in chronically infected cells via suppression of the NF-κB pathway. GUT-70 can be used for the study of leukemic, mantle cell lymphoma (MCL) and HIV-1 infection[1][2][3].

• UNSPSC:

  12352005

• Target:

  Apoptosis; Caspase; HIV; HSP; NF-κB

• Related Pathways:

  Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; NF-κB

• Field of Research:

  Cancer; Infection

• Smiles:

  O=C1C=C(CCC)C2=C3C(C=CC(C)(C)O3)=C(OC)C(C(/C(C)=C/C)=O)=C2O1

• Molecular Formula:

  C23H26O5

• Molecular Weight:

  382.45

• References & Citations:

  [1]Kimura S, et al. Inhibition of leukemic cell growth by a novel anti-cancer drug (GUT-70) from calophyllum brasiliense that acts by induction of apoptosis. Int J Cancer. 2005 Jan 1;113 (1) :158-65.|[2]Jin L, et al. Antiproliferative and proapoptotic activity of GUT-70 mediated through potent inhibition of Hsp90 in mantle cell lymphoma. Br J Cancer. 2011 Jan 4;104 (1) :91-100. |[3]Matsuda K, et al. Inhibition of HIV-1 entry by the tricyclic coumarin GUT-70 through the modification of membrane fluidity. Biochem Biophys Res Commun. 2015 Feb 13;457 (3) :288-94.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Caspase 2; Caspase 3; Caspase 8; Caspase 9; HIV-1; HSP90; NF-κB

• CAS Number:

  [161633-75-6]