BI 186908

• Description :

  BI 186908 is a selective and orally active MCH receptor 1 antagonist with an IC50 of 22 nM and a Ki of 14 nM. BI 186908 binds with comparably high affinity to the recombinant human, cynomolgus monkey (IC50 of 18 nM), dog (IC50 of 23 nM) and rat (IC50 of 18 nM) MCH-R1. BI 186908 can significantly reduce the body weight of diet-induced obese rats. BI 186908 can be used for the study of obesity[1].

• UNSPSC :

  12352005

• Target :

  MCHR1 (GPR24)

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Neurological Disease; Metabolic Disease

• Smiles :

  O=C1C=C(OCC2=NC=C(OC)C=C2)C=NN1CC(C3=CC=C(CN(C)C)C=C3C)=O

• Molecular Formula :

  C23H26N4O4

• Molecular Weight :

  422.48

• References & Citations :

  [1]Thorsten Oost, et al. Design, synthesis and evaluation of MCH receptor 1 antagonists--Part III: Discovery of pre-clinical development candidate BI 186908. Bioorg Med Chem Lett. 2015 Aug 15;25 (16) :3275-80.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1453500-36-1]