ML165

CAT: 0804-HY-120694Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-120694Size:1 Each
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Description
ML165 (RUC-2) is an aIIbb3 receptor antagonist. ML165 has orthosteric inhibition effect at the RGD binding domain. ML165 inhibits platelet adhesion to fibrinogen, and inhibits platelet aggregation (IC50: 96 nM) [1].
CAS Number
[1355454-05-5]
Product Name Alternative
RUC-2
UNSPSC
12352005
Target
Integrin
Related Pathways
Cytoskeleton
Field of Research
Cardiovascular Disease
Smiles
O=C(NC1=CC=CC(C(S2)=NN(C2=NC(N3CCNCC3)=C4)C4=O)=C1)CN
Molecular Formula
C17H19N7O2S
Molecular Weight
385.44
References & Citations
[1]Zhu J, et al. Structure-guided design of a high-affinity platelet integrin αIIbβ3 receptor antagonist that disrupts Mg²⁺ binding to the MIDAS. Sci Transl Med. 2012 Mar 14;4 (125) :125ra32.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
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