ML162-yne

• Description:

  ML162-yne is a potent GPX4-inhibitor affinity probe[1]. ML162-yne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H314

• Target:

  Glutathione Peroxidase

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ml162-yne.html

• Purity:

  99.06

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C (C (N (C1=CC=C (C (Cl) =C1) OCC#C) C (CCl) =O) C2=CC=CS2) NCCC3=CC=CC=C3

• Molecular Formula:

  C25H22Cl2N2O3S

• Molecular Weight:

  501.42

• Precautions:

  H302, H314

• References & Citations:

  [1]Eaton JK, et al. Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles. Nat Chem Biol. 2020 May;16 (5) :497-506.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  GPX4

• CAS Number:

  2883115-46-4