ML115

CAT: 0804-HY-111152-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-111152-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
ML115, a molecular probe of the signal transducer, is a selective STAT3 agonist, with an EC50 of 2 nM. ML115 increases the expression of BCL3, a known STAT3-dependent oncogene. ML115 is inactive against the related STAT1, STAT5 and NF-κB anti-targets. ML115 counteracts the effects of Ginsenoside Rc (HY-N0042) on cell viability and inflammatory responses in LPS (HY-D1056) -stimulated H9c2 and RAW264.7 cells, while altering oxidative stress markers. ML115 can be used for the study of breast and prostate cancers[1][2].
CAS Number
[912798-42-6]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
STAT
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ml115.html
Concentration
10mM
Purity
99.89
Solubility
DMSO : 20 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=NOC(C2CC2)=C1)NC3=CC(OC)=C(Cl)C=C3OC
Molecular Formula
C15H15ClN2O4
Molecular Weight
322.74
Precautions
H302, H315, H319, H335
References & Citations
[1]Jinzhong Wang MS, et al. STAT3/FoxO3a/Sirt1 pathway inhibition by ginsenoside Rc ameliorates cardiomyocyte damage in septic cardiomyopathy by altering macrophage polarization. J Mol Histol. 2025 Apr 28;56 (3) :148. |[2]Madoux F, et al. Modulators of STAT Transcription Factors for the Targeted Therapy of Cancer (STAT3 Activators) . 2009 Aug 27 [updated 2010 Dec 16]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD) : National Center for Biotechnology Information (US) ; 2010–.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
STAT3

Related Products

CatalogName
HY-115674ML175
HY-120694ML165
HY-128020ML114

Alternative Products

CatalogName
MBS5784901ML115

Popular Products