IDN-1965

CAT: 0804-HY-120257Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-120257Size:1 Each
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IDN-1965 is an irreversible, broad-spectrum caspase inhibitor. IDN-1965 prevents downstream apoptotic events (such as DNase activation) and significantly delays cytochrome c release by inhibiting caspase activity. IDN-1965 significantly delayed death in mice with cardiomyocyte apoptosis. IDN-1965 completely prevents left ventricular dilation, systolic dysfunction, and fibrosis in mice with dilated cardiomyopathy. IDN-1965 can be used to study apoptosis-related diseases such as heart failure and the mechanisms of apoptosis initiation[1][2].
CAS Number
[204919-14-2]
UNSPSC
12352005
Target
Apoptosis; Caspase
Related Pathways
Apoptosis
Applications
Neuroscience-Neurodegeneration
Field of Research
Cardiovascular Disease
Smiles
O=C(CC(C(CF)=O)NC([C@H](C(C)C)NC(C(N1C)=C(C2=C1C=CC=C2)C)=O)=O)O
Molecular Formula
C21H26FN3O5
Molecular Weight
419.45
References & Citations
[1]Wencker D, et al. A mechanistic role for cardiac myocyte apoptosis in heart failure. J Clin Invest. 2003 May;111 (10) :1497-504.|[2]Marsden VS, et al. Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome. Nature. 2002 Oct 10;419 (6907) :634-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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