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AW-814141

CAT: 0804-HY-119298Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-119298Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AW-814141 is a selective and orally active p38 MAP kinase inhibitor. AW-814141 has an IC50 values of 100 nM and 158 nM for p38-α and β isoforms, respectively. AW-814141 can inhibit the production of TNF-α induced by LPS. AW-814141 can inhibit paw edema in rats in a dose-dependent manner. AW-814141 exhibits anti-inflammatory activity and can be used in the research of inflammatory diseases such as rheumatoid arthritis[1].
CAS Number
905285-51-0
UNSPSC
12352005
Target
P38 MAPK
Related Pathways
MAPK/ERK Pathway
Field of Research
Inflammation/Immunology
Smiles
O=C1C(C2=CC=CC=C2C)=CC3=CN=C(NN4CC5C(CCC5)C4)N=C3N1C
Molecular Formula
C22H25N5O
Molecular Weight
375.47
References & Citations
[1]Chopra P, et al. Pharmacological profile of AW-814141, a novel, potent, selective and orally active inhibitor of p38 MAP kinase. Int Immunopharmacol. 2010 Apr;10 (4) :467-73.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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