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AD-35

CAT: 0804-HY-117710BSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-117710BSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AD-35 is an orally active anti-Alzheimer's disease (AD) agent with moderate AChE inhibitory activity and metal ion chelating ability. AD-35 exhibits IC50 values for AChE and BuChE of 793 nM and 31428 nM, respectively. AD-35 can form chelates with Cu²⁺ and Fe³⁺, but its chelating ability for Zn²⁺ is relatively weak. AD-35 can inhibit Aβ aggregation and disassemble the formed Aβ aggregates, and inhibit Aβ-induced ERK phosphorylation. AD-35 inhibits neuroinflammation in AD rat models and demonstrates a strong effect in improving cognitive function[1].
CAS Number
1531586-64-7
UNSPSC
12352005
Target
Amyloid-β; Cholinesterase (ChE) ; ERK; Interleukin Related; TNF Receptor
Related Pathways
Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Neuronal Signaling; Stem Cell/Wnt
Field of Research
Neurological Disease
Smiles
O=C(N(CCC1CCN(CC2=CC=CC=N2)CC1)C34CC4)C(C3=C5)=CC6=C5OCO6.OP(O)(O)=O
Molecular Formula
C24H30N3O7P
Molecular Weight
503.48
References & Citations
[1]Li L, et al. Multifunctional Compound AD-35 Improves Cognitive Impairment and Attenuates the Production of TNF-α and IL-1β in an Aβ25-35-induced Rat Model of Alzheimer's Disease. J Alzheimers Dis. 2017;56 (4) :1403-1417.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; IL-1

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