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J-104118

CAT: 0804-HY-116595Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-116595Size:1 Each
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Description
J-104118 is a potent and orally active squalene synthase (SQS) inhibitor with an IC50 of 0.52 nM. J-104118 inhibits cholesterol synthesis in mice. J-104118 can be used for cholesterol-lowering research[1].
CAS Number
172277-82-6
UNSPSC
12352005
Target
Farnesyl Transferase
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Metabolic Disease
Smiles
O=C([C@H](CC(O)=O)CC(N[C@@H](C)[C@@H](CC1=CC=C(C(Cl)=C1)Cl)C2=CC=C(C(F)=C2)C3=CC=CC=C3)=O)O
Molecular Formula
C28H26Cl2FNO5
Molecular Weight
546.41
References & Citations
[1]Iwasawa Y, et al. Synthesis and Biological Activity of J-104,118, a Novel, Potent Inhibitor of Squalene Synthase. Bioorganic & Medicinal Chemistry Letters 1995, 5 (17), 1989–1994.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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