TC9-305

CAT: 0804-HY-115806Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-115806Size:1 Each
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Description
TC9-305 is a potent and selective apoptosis inhibitor. TC9-305 has strong inhibitory activity against both Bim and tBid-induced apoptosis with EC50 values of 0.42 and 0.23 μM. TC9-305 can maintain the mitochondrial membrane potential, reduce ROS production, prevent the release of cytochrome c and block the upstream pathways of mitochondrial-mediated apoptosis. TC9-305 can be used for the research of neurological disease, such as storke[1].
CAS Number
[2092914-16-2]
UNSPSC
12352005
Target
Apoptosis; Mitochondrial Metabolism; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Neurological Disease
Smiles
O=C1C=CC(C2=NC(S(CCCC(NC34CC5CC(CC(C4)C5)C3)=O)(=O)=O)=NC(C(F)(F)F)=C2)=CN1CC6=CC=C(C(OC)=C6)OC
Molecular Formula
C33H37F3N4O6S
Molecular Weight
674.73
References & Citations
[1]Li L, et al. Discovery of Highly Potent 2-Sulfonyl-Pyrimidinyl Derivatives for Apoptosis Inhibition and Ischemia Treatment. ACS Med Chem Lett. 2017 Mar 1;8 (4) :407-412.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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