TC9-305

• Description:

  TC9-305 is a potent and selective apoptosis inhibitor. TC9-305 has strong inhibitory activity against both Bim and tBid-induced apoptosis with EC50 values of 0.42 and 0.23 μM. TC9-305 can maintain the mitochondrial membrane potential, reduce ROS production, prevent the release of cytochrome c and block the upstream pathways of mitochondrial-mediated apoptosis. TC9-305 can be used for the research of neurological disease, such as storke[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; Mitochondrial Metabolism; Reactive Oxygen Species (ROS)

• Related Pathways:

  Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Field of Research:

  Neurological Disease

• Smiles:

  O=C1C=CC (C2=NC (S (CCCC (NC34CC5CC (CC (C4) C5) C3) =O) (=O) =O) =NC (C (F) (F) F) =C2) =CN1CC6=CC=C (C (OC) =C6) OC

• Molecular Formula:

  C33H37F3N4O6S

• Molecular Weight:

  674.73

• References & Citations:

  [1]Li L, et al. Discovery of Highly Potent 2-Sulfonyl-Pyrimidinyl Derivatives for Apoptosis Inhibition and Ischemia Treatment. ACS Med Chem Lett. 2017 Mar 1;8 (4) :407-412.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2092914-16-2