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VUF11207 (TFA)

CAT: 0804-HY-115615Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-115615Size:1 Each
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Description
VUF11207 (Compound 29) TFA is a CXCR7 agonist (pKi of 8.1) that induces recruitment of β-arrestin2 (pEC50 of 8.8) and subsequent internalization (pEC50 of 7.9) of CXCR7[1].
CAS Number
1492153-74-8
UNSPSC
12352005
Target
CXCR
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Field of Research
Endocrinology
Solubility
10 mM in DMSO
Smiles
O=C(N(C/C(C)=C/C1=CC=CC=C1F)CCC2N(C)CCC2)C3=CC(OC)=C(OC)C(OC)=C3.FC(C(O)=O)(F)F
Molecular Formula
C29H36F4N2O6
Molecular Weight
584.60
References & Citations
[1]Wijtmans M, et al. Synthesis, modeling and functional activity of substituted styrene-amides as small-molecule CXCR7 agonists. Eur J Med Chem. 2012 May;51:184-92.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CXCR7

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