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EGIS-8332

CAT: 0804-HY-114975Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-114975Size:1 Each
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Description
EGIS-8332 is a non-competitive AMPA receptor antagonist. EGIS-8332 inhibits AMPA currents in rat cerebellar Purkinje cells and inhibited the AMPA- and Quisqualate-induced excitotoxicity in primary cultures of telencephalon neurons (IC50 = 5.1-9.0 μM) . EGIS-8332 exhibits anticonvulsant and neuroprotective effects. EGIS-8332 can be used for the research of neurological disease[1].
CAS Number
220725-87-1
UNSPSC
12352005
Target
IGluR
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
CC(N1C(CC2=CC3=C(OCO3)C=C2C(C4=CC=C(N)C=C4)=N1)(C)C#N)=O
Molecular Formula
C20H18N4O3
Molecular Weight
362.38
References & Citations
[1]Gigler G, et al. Neuroprotective and anticonvulsant effects of EGIS-8332, a non-competitive AMPA receptor antagonist, in a range of animal models. Br J Pharmacol. 2007 Sep;152 (1) :151-60.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AMPA Receptor

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