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EGIS-8332

CAT: 0931-T69806-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T69806-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
220725-87-1
Target
Others
Related Pathways
Others
Bioactivity
EGIS-8332 is a potent and selective non-competitive AMPA receptor antagonist. EGIS-8332 inhibits AMPA/kainate ion channels and cell death. EGIS-8332 inhibited AMPA currents in rat cerebellar Purkinje cells and inhibited the AMPA- and quisqualate-induced excitotoxicity in primary cultures of telencephalon neurons (IC (50) =5.1-9.0 microM), in vitro. EGIS-8332 seems suitable for further development for the treatment of epilepsy, ischaemia and stroke based on its efficacy in a variety of experimental disease models, and on its low side effect potential.
Smiles
C(C)(=O)N1N=C(C2=C(CC1(C#N)C)C=C3C(=C2)OCO3)C4=CC=C(N)C=C4
Molecular Formula
C20H18N4O3
Molecular Weight
362.38
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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