ARRY-371797

CAT: 0804-HY-114422Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-114422Size:1 Each
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Description
ARRY-371797 is a potent and orally active p38α MAPK and BChE inhibitor with IC50 values of 12.0, 0.13, > 100 µM for p38α MAP, hBChE, hAChE, respectively. ARRY-371797 has the potential for the research of Alzheimer’s disease[1].
CAS Number
[3077831-12-7]
UNSPSC
12352100
Target
Cholinesterase (ChE) ; p38 MAPK
Related Pathways
MAPK/ERK Pathway; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C(C1=CC2=NN(CC(C)C)C=C2C=C1OC3=CC=C(F)C=C3F)NCCN(C)C
Molecular Formula
C22H26F2N4O2
Molecular Weight
416.46
References & Citations
[1]Ferjančič Benetik S, et al. Targeting Neuroinflammation and Cognitive Decline: First-in-Class Dual Butyrylcholinesterase and p38α Mitogen-Activated Protein Kinase Inhibitors. J Med Chem. 2025 Aug 28;68 (16) :17378-17411.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; BChE; p38α

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