ARRY-371797

• Description :

  ARRY-371797 is a potent and orally active p38α MAPK and BChE inhibitor with IC50 values of 12.0, 0.13, > 100 µM for p38α MAP, hBChE, hAChE, respectively. ARRY-371797 has the potential for the research of Alzheimer’s disease[1].

• UNSPSC :

  12352100

• Target :

  Cholinesterase (ChE) ; p38 MAPK

• Related Pathways :

  MAPK/ERK Pathway; Neuronal Signaling

• Field of Research :

  Neurological Disease

• Smiles :

  O=C(C1=CC2=NN(CC(C)C)C=C2C=C1OC3=CC=C(F)C=C3F)NCCN(C)C

• Molecular Formula :

  C22H26F2N4O2

• Molecular Weight :

  416.46

• References & Citations :

  [1]Ferjančič Benetik S, et al. Targeting Neuroinflammation and Cognitive Decline: First-in-Class Dual Butyrylcholinesterase and p38α Mitogen-Activated Protein Kinase Inhibitors. J Med Chem. 2025 Aug 28;68 (16) :17378-17411.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  AChE; BChE; p38α

• CAS Number :

  [3077831-12-7]