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D3-βArr

CAT: 0804-HY-124867-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-124867-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
D3-βArr is a positive allosteric modulator for thyrotropin receptor (TSHR), which initiates translocation of β-Arr 1 by direct TSHR activation and potentiates TSH-mediated preosteoblast differentiation in vitro[1].
CAS Number
662164-09-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
TSH Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/d3-beta-arr.html
Purity
99.49
Solubility
DMSO : ≥ 125 mg/mL
Smiles
CC(NC1=C2C=CC=CC2=NC(N3CCNCC3)=N1)C4=CC=CC=C4
Molecular Formula
C20H23N5
Molecular Weight
333.43
Precautions
H302, H315, H319, H335
References & Citations
[1]Neumann S, et al. Discovery of a Positive Allosteric Modulator of the Thyrotropin Receptor: Potentiation of Thyrotropin-Mediated Preosteoblast Differentiation In Vitro. J Pharmacol Exp Ther. 2018 Jan;364 (1) :38-45.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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