Elexacaftor (Standard)

• Description:

  Elexacaftor (Standard) is the analytical standard of Elexacaftor. This product is intended for research and analytical applications. Elexacaftor (VX-445, Compound 1) is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR) . Elexacaftor (VX-445, Compound 1) facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell surface[1].

• UNSPSC:

  12352100

• Target:

  Autophagy; CFTR; Reference Standards

• Related Pathways:

  Autophagy; Membrane Transporter/Ion Channel; Others

• Field of Research:

  Inflammation/Immunology

• Smiles:

  CC1(C)C[C@H](C)CN1C2=C(C(NS(C3=CN(C)N=C3C)(=O)=O)=O)C=CC(N4C=CC(OCC(C)(C(F)(F)F)C)=N4)=N2

• Molecular Formula:

  C26H34F3N7O4S

• Molecular Weight:

  597.65

• References & Citations:

  [1]Alexander Russell Abela, et al. MODULATOR OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR , PHARMACEUTICAL COMPOSITIONS , METHODS OF TREATMENT , AND PROCESS FOR MAKING THE MODULATOR. US 20180162839 A1.|[2]Keating D, et al. VX-445-Tezacaftor-VX-770 in Patients with Cystic Fibrosis and One or Two Phe508del Alleles. N Engl J Med. 2018 Oct 25;379 (17) :1612-1620.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  2216712-66-0