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(S) -Padsevonil

CAT: 0804-HY-109009A-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-109009A-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(S) -Padsevonil is the S-enantiomer of Padsevonil.Padsevonil (UCB0942) is a potent antiepileptic agent that selectively acts on presynaptic and postsynaptic targets. Padsevonil binds to synaptic vesicular protein 2 (SV2) with high affinity. Padsevonil is also a positive allosteric modulator and partial agonist of GABAAR, with high potency against α1 and α5 receptors. Padsevonil has antiepileptic effects in a variety of rodent models[1][2].
CAS Number
1294001-37-8
Product Name Alternative
(S) -UCB-0942
UNSPSC
12352005
Target
GABA Receptor
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Purity
99.40
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O=C1N(C[C@H](CC(F)(F)Cl)C1)CC(N(N=C(COC)S2)C2=N3)=C3C(F)(F)F
Molecular Formula
C14H14ClF5N4O2S
Molecular Weight
432.80
References & Citations
[1]Niespodziany I, et al. Functional characterization of the antiepileptic drug candidate, padsevonil, on GABAA receptors. Epilepsia. 2020 May;61 (5) :914-923.|[2]Leclercq K, et al. Pharmacological Profile of the Novel Antiepileptic Drug Candidate Padsevonil: Characterization in Rodent Seizure and Epilepsy Models. J Pharmacol Exp Ther. 2020 Jan;372 (1) :11-20.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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