P-1075 (Standard)

• Description:

  P-1075 (Standard) is the analytical standard of P-1075. This product is intended for research and analytical applications. P-1075 is a potent activator of sulfonylurea receptor 2-associated ATP-sensitive potassium channels (SUR2-KIR6), with an EC50 value of 45 nM for SUR2B-KIR6 channel activation[1]. P-1075 also P1075 opens mitochondrial K (ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts[2].

• UNSPSC:

  12352100

• Target:

  Potassium Channel; Reference Standards

• Related Pathways:

  Membrane Transporter/Ion Channel; Others

• Field of Research:

  Cardiovascular Disease

• Smiles:

  CCC(N/C(NC#N)=N/C1=CC=CN=C1)(C)C

• Molecular Formula:

  C12H17N5

• Molecular Weight:

  231.30

• References & Citations:

  [1]Schwanstecher M, et al. Potassium channel openers require ATP to bind to and act through sulfonylurea receptors. EMBO J. 1998 Oct 1;17 (19) :5529-35.|[2]Oldenburg O, et al. P1075 opens mitochondrial K (ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts. J Mol Cell Cardiol. 2003 Sep;35 (9) :1035-42.|[3]Gross ER, et al. GSK3beta inhibition and K (ATP) channel opening mediate acute opioid-induced cardioprotection at reperfusion. Basic Res Cardiol. 2007 Jul;102 (4) :341-9.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  60559-98-0