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PF-06767832

CAT: 0804-HY-108340-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-108340-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PF-06767832 is a potent muscarinic M1 selective positive allosteric modulator (PAM), with the EC50 of 60 nM. PF-06767832 has good brain penetration[1].
CAS Number
1859081-58-5
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
MAChR
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O[C@@H](COCC1)[C@H]1NC(C2=CC(CC3=CC=C(C4=CSC=N4)C=C3)=C(C)C=N2)=O
Molecular Formula
C22H23N3O3S
Molecular Weight
409.50
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Jennifer E Davoren, et al. Discovery of the Potent and Selective M1 PAM-Agonist N-[ (3R,4S) -3-Hydroxytetrahydro-2H-pyran-4-yl]-5-methyl-4-[4- (1,3-thiazol-4-yl) benzyl]pyridine-2-carboxamide (PF-06767832) : Evaluation of Efficacy and Cholinergic Side Effects. J Med Chem. 2016 Jul 14;59 (13) :6313-28.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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