Propentofylline-d6

• Description:

  Propentofylline-d6 (HWA 285-d6) is the deuterium labeled Propentofylline. Propentofylline is a xanthine-derivative that inhibits adenosine uptake and blocks phosphodiesterase activity. Propentofylline has neuroprotective, antiproliferative, and anti-inflammatory effects that improve cognition and dementia severity in patients with Alzheimer's disease or vascular dementia[1][2].

• Product Name Alternative:

  HWA 285-d6

• UNSPSC:

  12352005

• Target:

  Isotope-Labeled Compounds; Phosphodiesterase (PDE)

• Related Pathways:

  Metabolic Enzyme/Protease; Others

• Field of Research:

  Inflammation/Immunology; Neurological Disease

• Solubility:

  10 mM in DMSO

• Smiles:

  C (CC) N1C2=C (N (C) C (=O) N (C (C (C (CC (C) =O) ([2H]) [2H]) ([2H]) [2H]) ([2H]) [2H]) C2=O) N=C1

• Molecular Formula:

  C15H16D6N4O3

• Molecular Weight:

  312.40

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Hudlicka O, Komarek J, Wright AJ. The effect of a xanthine derivative, 1- (5' oxohexyl) -3-methyl-7-propylxanthine (HWA 285), on heart performance and regional blood flow in dogs and rabbits. Br J Pharmacol. 1981;72 (4) :723-730. |[3]Sweitzer S, De Leo J. Propentofylline: glial modulation, neuroprotection, and alleviation of chronic pain. Handb Exp Pharmacol. 2011; (200) :235-250.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  1216516-37-8