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(E) -Hyzetimibe

CAT: 0804-HY-107176Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-107176Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(E) -Hyzetimibe ((E) -HS-25) (Compound I-1Z) is the trans isomer of Hyzetimibe , a cholesterol-lowering agent. (E) -Hyzetimibe has cholesterol acyltransferase (ACTA) inhibitory activity, but its cholesterol-lowering effect is relatively weak. (E) -Hyzetimibe can inhibit the entry of hepatitis C virus (HCV) into host cells, and it has a synergistic effect when used in combination with interferon-α. (E) -Hyzetimibe can be used for the study of HCV infection[1][2].
CAS Number
1266548-75-7
Product Name Alternative
(E) -HS-25
UNSPSC
12352005
Target
Acyltransferase; Drug Isomer; HCV
Related Pathways
Anti-infection; Metabolic Enzyme/Protease; Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Infection; Metabolic Disease
Smiles
OC/C(C1=CC=C(C=C1)F)=C/C[C@@H]2[C@@H](C3=CC=C(C=C3)O)N(C4=CC=C(C=C4)F)C2=O
Molecular Formula
C25H21F2NO3
Molecular Weight
421.44
References & Citations
[1]BAI Y, et al. Azetidinone compound used for prevention and/or treatment of hepatitis c, and composition of the compound. WO2014131371A1|[2]BAI Y, et al. Azetidinone compounds and medical use thereof. WO2011017907.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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