BGC-201259

CAT: 0804-HY-107047Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-107047Size:1 Each
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Description
BGC-201259 (RS-1259) is an orally active inhibitor that simultaneously targets acetylcholinesterase (AChE) (IC50 = 101 nM) and serotonin transporter (SERT) (IC50 = 42 nM) . BGC-201259 inhibits 5-HT receptor with an IC50 of 90 nM. BGC-201259 exhibits strong weak activity against the NA transporter (IC50 = 7.7 μM), L-type calcium channel (IC50 = 3.6 μM), σ receptor (IC50 = 2 μM), and sodium channel (IC50 = 5.1 μM) . BGC-201259 demonstrates synergistic potential in improving cognitive and emotional symptoms by balancing the inhibition of these two targets. BGC-201259 can be used in research on Alzheimer's disease[1][2].
CAS Number
[444667-97-4]
Product Name Alternative
RS-1259
UNSPSC
12352005
Target
5-HT Receptor; Calcium Channel; Cholinesterase (ChE) ; Serotonin Transporter; Sigma Receptor; Sodium Channel
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
CN[C@H](C1=CC=C(OC(N(C)C)=O)C=C1)CCOC2=CC=C([N+]([O-])=O)C=C2.CN[C@H](C3=CC=C(OC(N(C)C)=O)C=C3)CCOC4=CC=C([N+]([O-])=O)C=C4.O=C(O)/C=C/C(O)=O
Molecular Formula
C42H50N6O14
Molecular Weight
862.88
References & Citations
[1]Abe Y, et al. Pharmacological characterization of RS-1259, an orally active dual inhibitor of acetylcholinesterase and serotonin transporter, in rodents: possible treatment of Alzheimer's disease. J Pharmacol Sci. 2003 Sep;93 (1) :95-105. |[2]Toda N, Kaneko T, Kogen H. Development of an efficient therapeutic agent for Alzheimer's disease: design and synthesis of dual inhibitors of acetylcholinesterase and serotonin transporter. Chem Pharm Bull (Tokyo) . 2010 Mar;58 (3) :273-87.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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