Peplomycin (sulfate)

CAT: 0804-HY-106364ASize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-106364ASize:1 Each
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Description
Peplomycin (Bleomycin PEP) sulfate is an analog of Bleomycin (HY-108345) and an antitumor antibiotic. Peplomycin sulfate exhibits potent antitumor activity and relatively low pulmonary toxicity. Peplomycin sulfate can induce various skin abnormalities and trigger apoptosis in SSCKN cells of oral squamous cell carcinoma. Peplomycin sulfate can also induce pulmonary fibrosis. Peplomycin sulfate is applicable for the research of tumors, pulmonary fibrosis and other related diseases[1][2][3][4].
CAS Number
[70384-29-1]
Product Name Alternative
Bleomycin PEP (sulfate) ; Pepleomycin (sulfate)
UNSPSC
12352005
Target
Antibiotic; Apoptosis
Related Pathways
Anti-infection; Apoptosis
Field of Research
Cancer; Infection
Smiles
O=C(C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C)N[C@@](C(N[C@H](C)[C@@H](O)[C@H](C)C(N[C@]([C@H](O)C)([H])C(NCCC2=NC(C3=NC(C(NCCCN[C@H](C4=CC=CC=C4)C)=O)=CS3)=CS2)=O)=O)=O)([H])[C@H](C5=CNC=N5)O[C@H]6[C@H]([C@H]([C@H](O)[C@H](CO)O6)O)O[C@]7([H])[C@H]([C@H]([C@H](O)[C@@H](CO)O7)OC(N)=O)O.OS(O)(=O)=O
Molecular Formula
C61H90N18O25S3
Molecular Weight
1571.67
References & Citations
[1]Carter SK, et al. Peplomycin. Cancer Treat Rev. 1984 Dec;11 (4) :303-5. |[2]Asano Y, et al. A case of peplomycin-induced scleroderma. Br J Dermatol. 2004 Jun;150 (6) :1213-4. |[3]Okamura H, et al. Peplomycin-induced apoptosis in oral squamous carcinoma cells depends on bleomycin sensitivity. Oral Oncol. 2001 Jun;37 (4) :379-85. |[4]Osaki T, et al. Peplomycin, a bleomycin derivative, induces myofibroblasts in pulmonary fibrosis. Int J Exp Pathol. 2001 Aug;82 (4) :231-41.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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