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Guanadrel (sulfate)

CAT: 0804-HY-B1660Size: 1 EachDry Ice: NoHazardous: No
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Description
Guanadrel sulfate is an orally active, potent and postganglionic sympathetic inhibitor. Guanadrel sulfate lowers blood pressure by reducing systemic vascular resistance with little effect on cardiac output. Guanadrel sulfate is promising for research of hypertension[1].
CAS Number
22195-34-2
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/guanadrel-sulfate.html
Smiles
NC(NCC1OC2(CCCCC2)OC1)=N.O=S(O)(O)=O.[0.5]
Molecular Formula
C10H19N3O2.1/2H2SO4
Molecular Weight
262.32
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Palmer JD, et al. Guanadrel sulfate: a postganglionic sympathetic inhibitor for the treatment of mild to moderate hypertension. Pharmacotherapy. 1983 Jul-Aug;3 (4) :220-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched

Chemical Information

Guanadrel Sulfate

Guanadrel sulfate is an organic sulfate salt resulting from the reaction of 2 eq. guanadrel with 1 eq. sulfuric acid. A postganglionic adrenergic blocking agent formerly used for the management of hypertension, it has been largely superseded by other drugs less likely to cause orthostatic hypotension (dizzy spells on standing up or stretching). It has a role as an antihypertensive agent and an adrenergic antagonist. It contains a guanadrel(1+).

CAS Number22195-34-2
PubChem CID68552
IUPAC Namebis(2-(1,4-dioxaspiro[4.5]decan-3-ylmethyl)guanidine);sulfuric acid
Molecular FormulaC20H40N6O8S
Molecular Weight524.6
Topological Polar Surface Area249
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count10
Rotatable Bond Count4
Heavy Atom Count35
Formal Charge0
Complexity326
SMILES
C1CCC2(CC1)OCC(O2)CN=C(N)N.C1CCC2(CC1)OCC(O2)CN=C(N)N.OS(=O)(=O)O
InChI
InChI=1S/2C10H19N3O2.H2O4S/c2*11-9(12)13-6-8-7-14-10(15-8)4-2-1-3-5-10;1-5(2,3)4/h2*8H,1-7H2,(H4,11,12,13);(H2,1,2,3,4)
InChIKey
RTEVGQJRTFFMLL-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Guanadrel Sulfate
CAS: 22195-34-2
CID: 68552
Formula: C20H40N6O8S
MW: 524.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight524.6
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count10
Rotatable Bond Count4
Exact Mass524.26283343
Monoisotopic Mass524.26283343
Topological Polar Surface Area249 Ų
Heavy Atom Count35
Formal Charge0
Complexity326
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count2
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count3
Compound Is CanonicalizedYes

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