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Peplomycin

CAT: 0804-HY-106364Size: 1 EachDry Ice: NoHazardous: No
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Description
Peplomycin (Bleomycin PEP) is an analog of Bleomycin and an antitumor antibiotic. Peplomycin exhibits potent antitumor activity and relatively low pulmonary toxicity. Peplomycin can induce various skin abnormalities and trigger apoptosis in SSCKN cells of oral squamous cell carcinoma. Peplomycin can also induce pulmonary fibrosis. Peplomycin is applicable for the research of tumors, pulmonary fibrosis and other related diseases[1][2][3][4].
CAS Number
68247-85-8
Product Name Alternative
Bleomycin PEP; Pepleomycin
UNSPSC
12352005
Target
Antibiotic; Apoptosis
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/peplomycin.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C)N[C@@](C(N[C@H](C)[C@@H](O)[C@H](C)C(N[C@]([C@H](O)C)([H])C(NCCC2=NC(C3=NC(C(NCCCN[C@H](C4=CC=CC=C4)C)=O)=CS3)=CS2)=O)=O)=O)([H])[C@H](C5=CNC=N5)O[C@H]6[C@H]([C@H]([C@H](O)[C@H](CO)O6)O)O[C@]7([H])[C@H]([C@H]([C@H](O)[C@@H](CO)O7)OC(N)=O)O
Molecular Formula
C61H88N18O21S2
Molecular Weight
1473.59
References & Citations
[1]Carter SK, et al. Peplomycin. Cancer Treat Rev. 1984 Dec;11 (4) :303-5. |[2]Asano Y, et al. A case of peplomycin-induced scleroderma. Br J Dermatol. 2004 Jun;150 (6) :1213-4. |[3]Okamura H, et al. Peplomycin-induced apoptosis in oral squamous carcinoma cells depends on bleomycin sensitivity. Oral Oncol. 2001 Jun;37 (4) :379-85. |[4]Osaki T, et al. Peplomycin, a bleomycin derivative, induces myofibroblasts in pulmonary fibrosis. Int J Exp Pathol. 2001 Aug;82 (4) :231-41.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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GTR19221732-01Peplomycin
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