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Gusacitinib-d4

CAT: 0804-HY-103018SSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-103018SSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Gusacitinib-d4 (ASN-002-d4) is the deuterium labeled Gusacitinib. Gusacitinib (ASN-002) is an orally active dual SYK/JAK kinase inhibitor with IC50 values of 5, 46, 4, 11 and 8 nM for SYK, JAK1, JAK2, JAK3 and TYK2, respectively. Gusacitinib rapidly and significantly suppressed key inflammatory pathways implicated in atopic dermatitis pathogenesis. Gusacitinib can be used in the research of chronic hand eczema and cancers such as basal cell carcinoma[1][2].
Product Name Alternative
ASN-002-d4
UNSPSC
12352005
Target
Isotope-Labeled Compounds; JAK; Syk
Related Pathways
Epigenetics; JAK/STAT Signaling; Others; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Cancer; Inflammation/Immunology
Smiles
N#CCC1CCN(C2=NC(NC3=C([2H])C([2H])=C(N4CCC(O)CC4)C([2H])=C3[2H])=C5C(C=NNC5=O)=N2)CC1
Molecular Formula
C24H24D4N8O2
Molecular Weight
464.56
References & Citations
[1]Xie Z, et al. Small-Molecule Kinase Inhibitors for the Treatment of Nononcologic Diseases. J Med Chem. 2021 Feb 11;64 (3) :1283-1345. |[2]Garcia-Melendo C, et al. Janus Kinase Inhibitors in Dermatology: Part 1 - General Considerations and Applications in Vitiligo and Alopecia Areata. Actas Dermo-Sifiliográficas, 2021, 112 (6) : 503-515.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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