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BIIB021 (mesylate)

CAT: 0804-HY-10212ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-10212ASize:1 Each
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Description
BIIB021 (CNF2024) mesylate is the mesylate of BIIB021. BIIB021 is an orally active Hsp90 inhibitor. BIIB021 inhibits the proliferation of chronic myeloid leukemia (CML) cells, with IC50 values of K562, K562/G, 32Dp210, and 32Dp210-T315I cells are 513.99, 603.53, 110.08, and 148.07 nM, respectively. BIIB021 degrades BCR-ABL protein and inhibits the β-catenin/c-Myc pathway. BIIB021 can also induce autophagy in CML cells. BIIB021 can be used for the research of CML[1].
CAS Number
1225041-97-3
Product Name Alternative
CNF2024 (mesylate)
UNSPSC
12352005
Target
Autophagy; c-Myc; HSP; β-catenin
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Stem Cell/Wnt
Field of Research
Cancer
Smiles
O=S(O)(C)=O.ClC1=NC(N)=NC2=C1N=CN2CC3=NC=C(C)C(OC)=C3C
Molecular Formula
C15H19ClN6O4S
Molecular Weight
414.87
References & Citations
[1]He W, et al. Hsp90 inhibitor, BIIB021, induces apoptosis and autophagy by regulating mTOR-Ulk1 pathway in imatinib-sensitive and -resistant chronic myeloid leukemia cells. Int J Oncol. 2016 Apr;48 (4) :1710-20.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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