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BIIB021 mesylate

CAT: 0013-GTR19273231-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19273231-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BIIB021 (CNF2024) mesylate is the mesylate salt form of BIIB021. BIIB021 is an orally active Hsp90 inhibitor. It suppresses the proliferation of drug-resistant chronic myeloid leukemia (CML) cells, with IC50 values for K562, K562/G, 32Dp210, and 32Dp210-T315I cells recorded at 513.99, 603.53, 110.08, and 148.07 nM, respectively. BIIB021 induces the degradation of BCR-ABL protein and inhibits the β-catenin/c-Myc pathway. Furthermore, BIIB021 can induce autophagy in CML cells and is applicable for CML research.
CAS Number
1225041-97-3
Smiles
O=S (=O) (O) C.ClC1=NC (=NC2=C1N=CN2CC3=NC=C (C (OC) =C3C) C) N
Molecular Formula
C15H19ClN6O4S
Molecular Weight
414.87
Storage Conditions
-20°C
Notes
For research use only.

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