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EIPA (Standard)

CAT: 0804-HY-101840R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-101840R-01Size:5 mg
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Description
EIPA (Standard) is the analytical standard of EIPA. This product is intended for research and analytical applications. EIPA (L593754) is an orally active TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA also enhances autophagy by inhibiting Na+/H+-exchanger 3 (NHE3) . EIPA inhibits macropinocytosis as well. EIPA can be used in the research of inflammation and cancers, such as gastric cancer, colon carcinoma, pancreatic carcinoma[1][2][3][4][5][6][7].
CAS Number
1154-25-2
Product Name Alternative
L593754 (Standard) ; MH 12-43 (Standard) ; Ethylisopropylamiloride (Standard)
UNSPSC
12352005
Target
Autophagy; COX; Na+/H+ Exchanger (NHE) ; Prostaglandin Receptor; Reference Standards; TRP Channel
Related Pathways
Autophagy; GPCR/G Protein; Immunology/Inflammation; Membrane Transporter/Ion Channel; Neuronal Signaling; Others
Field of Research
Cancer; Inflammation/Immunology
Smiles
O=C(C1=NC(Cl)=C(N(CC)C(C)C)N=C1N)NC(N)=N
Molecular Formula
C11H18ClN7O
Molecular Weight
299.76
References & Citations
[1]Dai XQ, et al. Inhibition of TRPP3 channel by MK-870 and analogs. Mol Pharmacol. 2007 Dec;72 (6) :1576-85.|[2]Shi H, et al. Na+/H+ Exchanger Regulates Amino Acid-Mediated Autophagy in Intestinal Epithelial Cells. Cell Physiol Biochem. 2017;42 (6) :2418-2429.|[3]Zhu BY, et al. A new HDAC inhibitor cinnamoylphenazine shows antitumor activity in association with intensive macropinocytosis.|[4]E V Stelmashook, et al. Acidosis and 5- (N-ethyl-N-isopropyl) amiloride (EIPA) Attenuate Zinc/Kainate Toxicity in Cultured Cerebellar Granule Neurons. Biochemistry (Mosc) . 2015 Aug;80 (8) :1065-72. |[5]Shigekuni Hosogi, et al. An inhibitor of Na (+) /H (+) exchanger (NHE), ethyl-isopropyl amiloride (EIPA), diminishes proliferation of MKN28 human gastric cancer cells by decreasing the cytosolic Cl (-) concentration via DIDS-sensitive pathways. Cell Physiol Biochem. 2012;30 (5) :1241-53.|[6]Junji Yamashita, et al. Role of Na+/H+ exchanger in the pathogenesis of ischemic acute renal failure in mice. J Cardiovasc Pharmacol. 2007 Mar;49 (3) :154-60. |[7]Fumitaka Kamachi, et al. Inhibition of lipopolysaccharide-induced prostaglandin E2 production and inflammation by the Na+/H+ exchanger inhibitors. J Pharmacol Exp Ther. 2007 Apr;321 (1) :345-52.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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