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EIPA (hydrochloride) (Standard)

CAT: 0804-HY-101840AR-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-101840AR-01Size:5 mg
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Description
EIPA (hydrochloride) (Standard) is the analytical standard of EIPA (hydrochloride) . This product is intended for research and analytical applications. EIPA (L593754) hydrochloride is an orally active TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA hydrochloride also enhances autophagy by inhibiting Na+/H+-exchanger 3 (NHE3) . EIPA hydrochloride inhibits macropinocytosis as well. EIPA hydrochloride can be used in the research of inflammation and cancers, such as gastric cancer, colon carcinoma, pancreatic carcinoma[1][2][3][5].
CAS Number
1345839-28-2
Product Name Alternative
L593754 (hydrochloride) (Standard) ; MH 12-43 (hydrochloride) (Standard) ; Ethylisopropylamiloride (hydrochloride) (Standard)
UNSPSC
12352005
Target
Autophagy; COX; Na+/H+ Exchanger (NHE) ; Prostaglandin Receptor; Reference Standards; TRP Channel
Related Pathways
Autophagy; GPCR/G Protein; Immunology/Inflammation; Membrane Transporter/Ion Channel; Neuronal Signaling; Others
Field of Research
Cancer; Inflammation/Immunology
Smiles
O=C(C1=NC(Cl)=C(N(CC)C(C)C)N=C1N)NC(N)=N.Cl
Molecular Formula
C11H19Cl2N7O
Molecular Weight
336.22
References & Citations
[1]Dai XQ, et al. Inhibition of TRPP3 channel by MK-870 and analogs. Mol Pharmacol. 2007 Dec;72 (6) :1576-85.|[2]Shi H, et al. Na+/H+ Exchanger Regulates Amino Acid-Mediated Autophagy in Intestinal Epithelial Cells. Cell Physiol Biochem. 2017;42 (6) :2418-2429.|[3]Zhu BY, et al. A new HDAC inhibitor cinnamoylphenazine shows antitumor activity in association with intensive macropinocytosis.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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