β-Funaltrexamine (hydrochloride)

CAT: 0804-HY-101318-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-101318-01Size:1 mg
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Description
β-Funaltrexamine (β-FNA) hydrochloride is a selective μ opioid receptor antagonist. β-Funaltrexamine hydrochloride also inhibits cytokine-induced iNOS activation. β-Funaltrexamine hydrochloride inhibits neuroinflammation and ameliorated neuronal degeneration. β-Funaltrexamine hydrochloride has anti-inflammatory and neuroprotective effects and can be used for research of neurodegenerative diseases (eg: stroke) [1][2]
CAS Number
[72786-10-8]
Product Name Alternative
β-FNA (hydrochloride)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
NO Synthase; Opioid Receptor
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Purity
99.07
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O[C@]1([C@@]2([H])CC3=CC=C4O)[C@@]5(CCN2CC6CC6)C3=C4O[C@@]5([H])[C@H](NC(/C=C/C(OC)=O)=O)CC1.Cl
Molecular Formula
C25H31ClN2O6
Molecular Weight
490.98
Precautions
H302, H315, H319, H335
References & Citations
[1]Wu CC, et al. β-Funaltrexamine Displayed Anti-inflammatory and Neuroprotective Effects in Cells and Rat Model of Stroke. Int J Mol Sci. 2020 May 29;21 (11) :3866.|[2]Ward SJ, et al. Pharmacological profiles of beta-funaltrexamine (beta-FNA) and beta-chlornaltrexamine (beta-CNA) on the mouse vas deferens preparation. Eur J Pharmacol. 1982 Jun 4;80 (4) :377-84.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
INOS; μ Opioid Receptor/MOR

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