QS-21

• Description:

  QS-21 is a mixture of QS-21-Xyl (HY-101092B) and QS-21-Api (HY-101092), with a ratio of 35:65. QS-21 is an innate immune system-targeted adjuvant. QS-21 is promising for research of oncology vaccines (e.g., melanoma) and infectious disease vaccines (e.g., HIV, malaria) [1].

• UNSPSC:

  12352005

• Target:

  Toll-like Receptor (TLR)

• Related Pathways:

  Immunology/Inflammation

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Infection

• Smiles:

  O[C@H]1COC[C@@H] (O) [C@@H]1O.O[C@H]2COC[C@]2 (O) CO.O[C@H] ([C@@H] ([C@H] ([C@@H] (O3) C) O[C@H]4[C@@H] ([C@H] ([C@@H] (CO4) O) O[R]) O) O) [C@@H]3O[C@H] ([C@H] ([C@H] ([C@H] (O5) C) OC (C[C@@H] (O) C[C@H] (OC (C[C@@H] (O) C[C@@H] ([C@@H] (C) CC) O[C@@H]6O[C@H] ([C@@H] ([C@H]6O) O) CO) =O) [C@H] (CC) C) =O) O) [C@@H]5OC ([C@]78[C@] (CC (C) (CC8) C) ([H]) C9=CC[C@@] ([C@@]%10 ([C@@] ([C@@] (C) ([C@H] (CC%10) O[C@H]%11[C@@H] ([C@H] ([C@@H] ([C@H] (O%11) C (O) =O) O) O[C@H]%12[C@@H] ([C@H] ([C@@H] (CO%12) O) O) O) O[C@@H]%13O[C@@H] ([C@@H] ([C@@H] ([C@H]%13O) O) O) CO) C=O) ([H]) CC%14) C) ([H]) [C@]%14 (C) [C@@]9 (C[C@H]7O) C) =O.[35%].[65%]

• Molecular Formula:

  C92H148O46

• Molecular Weight:

  1990.14

• References & Citations:

  [1]Deng K, et al. Synthesis of QS-21-xylose: establishment of the immunopotentiating activity of synthetic QS-21 adjuvant with a melanoma vaccine. Angew Chem Int Ed Engl. 2008;47 (34) :6395-8.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported