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Fmoc-leucine (Standard)

CAT: 0804-HY-101064RSize: 1 EachDry Ice: NoHazardous: No
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Description
Fmoc-leucine (Standard) is the analytical standard of Fmoc-leucine. This product is intended for research and analytical applications. Fmoc-leucine is a selective PPARγ modulator. Fmoc-leucine activates PPARγ with a lower potency but a similar maximal efficacy than rosiglitazone. Fmoc-leucine improves insulin sensitivity in normal, diet-induced glucose-intolerant, and in diabetic db/db mice. Fmoc-leucine has a lower adipogenic activity[1].
CAS Number
35661-60-0
Target
PPAR; Reference Standards
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor
Field of Research
Metabolic Disease
Smiles
CC(C)C[C@@H](C(O)=O)NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O
Molecular Formula
C21H23NO4
Molecular Weight
353.42
References & Citations
[1]Rocchi S, et al. A unique PPARgamma ligand with potent insulin-sensitizing yet weak adipogenic activity. Mol Cell. 2001 Oct;8 (4) :737-47.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

Chemical Information

Fmoc-leucine

a leumedin; RN given for (L)-isomer

CAS Number35661-60-0
PubChem CID1549133
IUPAC Name(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methylpentanoic acid
Molecular FormulaC21H23NO4
Molecular Weight353.4
XLogP4.4
Topological Polar Surface Area75.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count7
Heavy Atom Count26
Formal Charge0
Complexity484
SMILES
CC(C)C[C@@H](C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13
InChI
InChI=1S/C21H23NO4/c1-13(2)11-19(20(23)24)22-21(25)26-12-18-16-9-5-3-7-14(16)15-8-4-6-10-17(15)18/h3-10,13,18-19H,11-12H2,1-2H3,(H,22,25)(H,23,24)/t19-/m0/s1
InChIKey
CBPJQFCAFFNICX-IBGZPJMESA-N
Chemical Structure
2D Structure
2D structure of Fmoc-leucine
CAS: 35661-60-0
CID: 1549133
Formula: C21H23NO4
MW: 353.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight353.4
XLogP34.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count7
Exact Mass353.16270821
Monoisotopic Mass353.16270821
Topological Polar Surface Area75.6 Ų
Heavy Atom Count26
Formal Charge0
Complexity484
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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